Skip to Search, Skip to Main navigation, Skip to local navigation, Skip to Content
Indiana University Purdue University Indianapolis
  •  
  •  

Colloquia Archive

Mobius: A Molecular and Biological Information

March 27, 2007

Host: Kelsey M. Forsythe

Abstract

Mobius (Molecular and Biological Information Utilization System) is software that has been designed to access, analyze and display information about Lilly’s compound collection. This information includes substance data such as dry inventory; physical and analytical data such as proton NMR spectra; biological assay data from multiple sources; and ADME/TOX (surrogate) data. In addition to accessing information on Lilly compounds, Mobius can also access a wide variety of external data including chemogenomic data (via the Biosel database), MDDR, and Available Compounds Directory (ACD). Mobius is very fast, fairly easy to learn and use and is targeted for all discovery scientists, not just chemists or biologists. This talk will discuss the Mobius’s functionality and illustrate why it is an extremely powerful discovery tool. In addition, principles behind its development and lessons learned over more than 20 years in the field will be shared.

Biography

Before joining Eli Lilly and Company in 2003, Mic was at the Upjohn Company (Pharmacia) for more than 28 years where he was awarded the prestigious Upjohn award for his work in structural diversity. He was one of the first to develop and apply computer-based methods to select high-quality, structurally diverse compounds for purchase as part of a compound enrichment program. His current interests are in developing novel techniques to understand and exploit the relationship between molecular structure and biological activity. Since joining Lilly, Mic has won the Lilly President’s Award and co-developed Mobius, which has transformed the way Lilly exploits drug discovery data. Mic’s educational background encompasses biology, chemistry, mathematics, and computer science. He is a reviewer for JMedChem, JCICS, JCIM, JACS, and Current Contents in Drug Discovery and Development. He is also on the editorial board of the Journal of Chemical Biology and a past chairman of the SAS Users Group International (SUGI) Conference (1999) and is a member of the newly formed SAS Global Forum (SGF) Executive Council.